Translational Research

Advancing Human Health

In its mission to advance human health, the Department of Surgery has for decades conducted the full spectrum of bench-to-bedside scientific investigations — an approach now known as translational research. Our large, multidisciplinary faculty work collaboratively on all four phases of translational research, designated T1-T4, to uncover the roots of disease, develop potential solutions, determine the best methods of application, and finally, examine and address factors that may affect implementation at a population level. With this approach, we aim to maximize our impact on building a healthier tomorrow.

T1: Translation to Humans

Discover the roots of disease and propose potential clinical solutions

  • Discover new disease mechanisms
  • Develop potential new approaches for diagnosis, therapy and prevention
  • Test effect and feasibility in animals and humans

T2: Translation to Patients

Test effectiveness in clinical trials

  • Assess safety and effectiveness (phase II and III)

T3: Translation to Practice

Determine optimal implementation in clinical practice

  • Refine the details: Who should receive it? How much? When?
  • Study cost effectiveness
  • Compare effectiveness with existing options

T4: Translation to Population

Examine the factors that affect the health of a population

  • Identify social determinants of health
  • Evaluate best ways to disseminate and adopt best practices
  • Identify and resolve barriers to implementation