Advancing Human Health
In its mission to advance human health, the Department of Surgery has for decades conducted the full spectrum of bench-to-bedside scientific investigations — an approach now known as translational research. Our large, multidisciplinary faculty work collaboratively on all four phases of translational research, designated T1-T4, to uncover the roots of disease, develop potential solutions, determine the best methods of application, and finally, examine and address factors that may affect implementation at a population level. With this approach, we aim to maximize our impact on building a healthier tomorrow.
T1: Translation to Humans
Discover the roots of disease and propose potential clinical solutions
- Discover new disease mechanisms
- Develop potential new approaches for diagnosis, therapy and prevention
- Test effect and feasibility in animals and humans
T2: Translation to Patients
Test effectiveness in clinical trials
- Assess safety and effectiveness (phase II and III)
T3: Translation to Practice
Determine optimal implementation in clinical practice
- Refine the details: Who should receive it? How much? When?
- Study cost effectiveness
- Compare effectiveness with existing options
T4: Translation to Population
Examine the factors that affect the health of a population
- Identify social determinants of health
- Evaluate best ways to disseminate and adopt best practices
- Identify and resolve barriers to implementation